The Bacterial Endotoxins Levels in the Blood of Cirrhotic Patients as Predictor of the Risk of Esophageal Varices Bleeding

In cirrhotic patients the bleeding from esophageal varices is the most dangerous complication of portal hypertension and is attended with high rate of lethality. Endoscopic assessment of esophageal varices and the state of esophageal and stomach mucosa at the esophagogastroduodenoscopy presents high importance for the assessment of risk of their development (Coelho-Prabhu & Kamath, 2010). However, invasiveness as well as discomfort that are tolerated by patients during the given procedure, lead to the rejection from it and therefore they can’t be subjected to examination in a number of cases. Besides, the research might be impossible to carry out in case if the state of patient is grave (de Franchis et al., 2008). The investigation of hepatic venous pressure gradient, that reflects the portal hypertension intensity best of all haven`t been realized in the clinical practice up to now (Groszmann et al., 2006). Considering the above mentioned disadvantages of main methods, the development of additional prognostic criteria of the risk of esophageal varices bleeding remains the urgent problem of the internal medicine (Cárdenas & Ginès, 2009).